How to make a Django+Ember application run on a domain name and a certain port number

I want to run a Django+Ember website on my website on a certain port number (eg. 54321), for example: domain-name.com:54321.

I got the Django+ember application working on my domain name (without the port number specified) like domain-name.com. I can not get it working with the command:

python3 manage.py runserver domain-name.com:54321

Do I need to add anything to my /etc/httpd/conf/httpd.conf file? I know my current configuration for the httpd.conf file is correct because it works without a port number. But what am I missing to make it work on a certain port number?